Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat
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منابع مشابه
Thyroid control of sarcolemmal Na+/Ca2+exchanger and SR Ca2+-ATPase in developing rat heart.
Thyroid hormone (TH) levels increase in the postnatal life and are essential for maturation of myocardial Ca2+ handling. During this time, the sarcolemmal (SL) Na+/Ca2+exchanger (NCX) function decreases and the sarco endoplasmic reticulum (SR) Ca2+-ATPase (SERCA2) function increases. We examined the effects of postnatal hypo- or hyperthyroidism on NCX and SERCA2 in rat hearts. Animals were rend...
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Hypertrophied and failing cardiac myocytes generally show alterations in intracellular Ca2+ handling associated with changes in the contractile function and arrhythmogenicity. The cardiac Na+-Ca2+ exchange (NCX) is an important mechanism for Ca2+ extrusion and cell relaxation. Its possible involvement in changes of excitation-contraction coupling (EC-coupling) with disease remains uncertain. We...
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To identify the functional unit of Ca(2+)-ATPase in the sarcoplasmic reticulum, we assessed Ca(2+)-transport activities occurring on sarcoplasmic reticulum membranes with different combinations of active and inactive Ca(2+)-ATPase molecules. We prepared heterodimers, consisting of a native Ca(2+)-ATPase molecule and a Ca(2+)-ATPase molecule inactivated by FITC labelling, by fusing vesicles load...
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Prevention of adverse cardiac remodeling after myocardial infarction (MI) remains a therapeutic challenge. Angiotensin-converting enzyme inhibitors (ACE-I) are a well-established first-line treatment. ACE-I delay fibrosis, but little is known about their molecular effects on cardiomyocytes. We investigated the effects of the ACE-I delapril on cardiomyocytes in a mouse model of heart failure (HF...
متن کاملElectrogenicity of Ca2+ transport catalyzed by the Ca2+-ATPase from sarcoplasmic reticulum.
The Ca’+-ATPase was isolated from sarcoplasmic reticulum and reconstituted into liposomes by the freezethaw-sonication procedure of Kasahara and Hinkle (Kasahara, M., and Hinkle, P. C. (1977) J. Biol. Chem 252, 7384-7390) with egg yolk phosphatidylcholine as the only phospholipid. By varying the ion concentrations during reconstitution and assay, different K+ gradients across the membrane were ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2008
ISSN: 0008-6363
DOI: 10.1093/cvr/cvn285